<p>Lemierre disease (LD) is a rare but potentially life-threatening condition, characterized internal jugular vein suppurative thrombophlebitis and disseminated septic emboli following a recent oropharyngeal infection. It is seen commonly in healthy young adolescents or adults, caused by gram negative anerobic <em>Fusoform necropharum</em>. Lack of awareness of this condition delays treatment and worsens prognosis. We present two interesting cases of LD in diabetic patients, caused by <em>Klebsiella pneumonia</em> and <em>Haemophilus influenza</em> organisms at our hospital. Both patients had atypical presentations. Diagnosis of such atypical cases poses diagnostic and therapeutic challenges.</p>