Background: Hypertension is well confirmed as a major risk factor for cardiovascular disease. Researches in the treatment of hypertension has produced a multitude of drug classes with different efficacy profiles, which including β-blockers, diuretics, ACE inhibitors, angiotensin receptor blockers and calcium channel blockers. This study aimed to investigate the effects of captopril and amlodipine on some of reproductive abilities. Materials and Methods: The laboratory mice were 10-12 weeks and 23-25 g divided into three groups, six mice of each one. Group A served as control group; injected with 0.1 ml of normal saline, group B; injected with 0.1 ml of Captopril with 0.2 mg / kg, group C injected with 0.1 ml of amlodipine 0.08 mg / kg. Results: Decrease in sperm count and testis weights and testosterone hormone of Amlodipine treated mice. While the numbers of sperms and testis weight of captopril treated mice were comparable to that of control groups. But decrease normal sperms of captopril and Amlodipine treated mice comparable to that of control group. Conclusion: These results suggest that the treatment with amlodipine causes a significant testicular weight regression and reduction in sperm count.

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