In this study, several neuropharmacological effects of methanolic leaf extract of Pandanus odoratissimus (PO) (family; Pandanaceae) were studied in albino mice using various experimental models. The effect of PO on the CNS was studied by using different neuropharmacological paradigms including spontaneous motor activity, rota-rod performance and potentiation of Pentobarbital sodium sleeping time in albino mice. Preliminary phytochemical evaluation and acute toxicity studies were also carried out where LD 50 >2000 mg/kg was considered non-toxic through acute exposure in rats by the oral route. The methanolic leaf extract (50,100 and 200 mg/kg i. p.) produced a reduction in spontaneous motor activity, motor coordination and prolonged Pentobarbital sodium sleeping time. Preliminary qualitative chemical studies indicated the presence of steroids, saponins, terpinoids, glycosides, tannins, flavonoids and phenolics in the extract. These observations suggest that the leaf of Pandanus odoratissimus contains some active principles which possess potential CNS-depressant action Uniterms: Pandanus odoratissimus/pharmacognosy. CNS-depressant action/experimental study. Spontaneous motor activity. Rota-rod performance. Sodium pentobarbital/potentiation of sleeping time.Estudaram-se alguns efeitos neurofarmacológicos do extrato metanólico de Pandanus odoratissimus (PO) (família Pandanaceae) em camundongos albinos, usando vários modelos experimentais. O efeito do PO no SNC foi estudado por meio de diferentes paradigmas neurofarmacológicos, como atividade motora espontânea, desempenho na haste rotatória e a potenciação do tempo de sono em camundongos albinos pelo pentobarbital sódico. A avaliação fitoquímica preliminar e os estudos de toxicidade aguda foram realizados e a DL 50 >2000 mg/kg é considerada não tóxica, por meio da exposição aguda, por via oral, em ratos. O extrato metanólico de folha (50,100 e 200 mg/kg i. p.) produziu redução da atividade motora espontânea, da coordenação motora e tempo prolongado de sono pelo pentobarbital sódico. Estudos químicos qualitativos preliminares indicaram a presença de esteróide, saponinas, terpenóides, glicosídios, taninos, flavonóides e fenólicos no extrato. As observações sugerem que a folha de Pandanus odoratissimus contém alguns princípios ativos com atividade potencial como depressores do SNC. Unitermos:Pandanus odoratissimus/farmacognosia. Ação depressor do SNC/estudo experimental. Atividade motora espontânea. Desempenho na haste rotatória. Pentobarbital sódico/potenciação no tempo de sono.

The current section is dedicated to collect information from participants about their experience while using in-person mode of delivery of Mobility India's (MI) rehabilitative and assisted technology services. The interviewer is requested to confirm with participants if they availed in-person services with MI during the period of June to October 2020. Kindly proceed after taking AV consent.

No abstract

No abstract

Background Parents who have young children with complex physical disabilities face challenges that are both physically and emotionally demanding. Parents of children with disabilities spend more time providing child assistance and supervision than other parents.Aim To determine the parent-perceived effects of adaptive positional seating and standing devices for children with delay in developmental milestones aged 2 to 14 years.Method The present study was conducted at Mobility India outpatient rehab clinic urban slums of the Bengaluru City Rural Chamrajnagar District Karnataka and two rehabilitation centres in Andhra Pradesh. A cross-sectional study was designed in which 52 parents of children with cerebral palsy were interviewed with QUEST Version 2.0 the pre and post usage positional device questionnaires. Results The usage of the pre positional device questionnaire reported that child positioning child-caring was time taking amp burdensome parent engagement in household and earning activities was difficult. The usage of the post positional devices reported that it helped to achieve near-normal positioning helped in feeding child enhanced eye contact with siblings and family members and improved communication by signing and indication. Parents took less time in child feeding caring with positional devices and engaged themselves in the household and earning activities. The positional devicersquos usage showed a significant effect on achieving milestones and also provided therapeutic benefits.Conclusion The parentrsquos perceived effects on the usage of the adaptive positional device for children with delayed developmental milestones were that it helped in physical abilities communication psychosocial and personal care. The parents felt relief from long-term engagement with children which created enough time for household and earning activities.