Small planets are common around late-M dwarfs and can be detected through highly precise photometry by the transit method. Planets orbiting nearby stars are particularly important as they are often the best-suited for future follow-up studies. We present observations of three nearby M-dwarfs referred to as EIC-1, EIC-2, and EIC-3, and use them to search for transits and set limits on the presence of planets. On most nights our observations are sensitive to Earth-sized transiting planets, and photometric precision is similar to or better than TESS for faint late-M dwarfs of the same magnitude (I ≈ 15 mag). We present our photometry and transit search pipeline, which utilizes simple median detrending in combination with transit least squares based transit detection (Hippke & Heller 2019). For these targets, and transiting planets between one and two Earth radii, we achieve an average transit detection probability of∼60% between periods of 0.5 and 2 days, ∼30% between 2 and 5 days, and ∼10% between 5 and 10 days. These sensitivities are conservative compared to visual searches.

Highlights d We isolate a non-neutralizing antibody from PyCSPimmunized BALB/cJ mice d A non-neutralizing Ab, RAM1, abrogates the blocking capacity of an aCSP NAb d A non-neutralizing Ab, RAM1, reduces the vaccine efficacy in mice in vivo d Further exploration for the role of pre-existing nNAbs in the field is warranted

Purpose: To investigate dynamic foveal morphology with postmenstrual age, in preterm infants with and without retinopathy of prematurity using hand-held optical coherence tomography, adjusting for gestational age (GA) and birthweight (BW). Methods: Prospective mixed cross-sectional/longitudinal observational study of 87 participants (23-36 weeks GA; n = 30 with, n = 57 without retinopathy of prematurity) using hand-held optical coherence tomography images (n = 278) acquired between 31 weeks and 44 weeks postmenstrual age excluding treated retinopathy of prematurity. Measurements included foveal width, area, depth, central foveal thickness, maximum slope, and parafoveal retinal thickness at 1,000 mm nasal and temporal to the central fovea. Results: Retinopathy of prematurity was significantly correlated with only foveal width in either GA or BW adjusted statistical models. In contrast, severity of prematurity (GA, BW) correlated with foveal area (P , 0.005), depth (P # 0.001), and slope (P , 0.01), although central foveal thickness (P = 0.007) and parafoveal retinal thickness (P , 0.001) correlated with GA, but not with BW. Conclusion: Foveal width is independent of GA and BW with potential in retinopathy of prematurity screening assessment using hand-held optical coherence tomography. Foveal morphology could be graded in prematurity during development, with possible implications for future management of preterm infants.

N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine 12 (GSK962040) is a novel small molecule motilin receptor agonist. It possesses excellent activity at the recombinant human motilin receptor and also at the native rabbit motilin receptor where its agonist activity results in potentiation of the amplitude of neuronal-mediated contractions of isolated gastric antrum tissue. Compound 12 also possesses highly promising pharmacokinetic profiles in both rat and dog, and these results, in combination with further profiling in human native tissue and an in vivo model of gastrointestinal transit in the rabbit, have led to its selection as a candidate for further development.