Research has found that Mexican American adolescents report higher levels of depressive symptoms than Whites and African Americans. For these youth, bicultural stress from navigating between their culture of origin and the mainstream U.S. culture can have negative mental health effects including higher levels of depressive symptoms and suicidal ideation. This study looks at the effects of bicultural stress and gender on depression and suicidal ideation of 516 Mexican American adolescents. Hierarchical linear and logistic regressions were performed to determine the affect of gender, bicultural stressors, and their interaction on depressive symptoms and suicidal ideation. Results indicate gender moderates the effect of several bicultural stressors on mental health outcomes, with boys being more affected by high levels of stress in areas when interaction effects were present. Discussion of results is framed within the intersection of ethnicity and gender role socialization.