No abstract

A series of pyrrole and pyrrolopyrimidine derivatives were examined for their in vivo antihyperglycemic activity. Compounds Ia–c,e, and IVg showed promising antihyperglycemic activity equivalent to a well-known standard antihyperglycemic drug, Glimepiride (Amaryl, 4 mg/kg). In this paper, we examine and discuss the structure-activity relationships and antihyperglycemic activity of these compounds.

We herein disclose a series of novel pyrrole derivatives 1-4 and pyrrolo[2,3-d]pyrimidine derivatives 6-11 as novel potent anti-inflammatory compounds. The structures were confirmed by IR, (1) H-NMR, and MS. Some newly synthesized compounds were examined for their in-vivo anti-inflammatory activity. Several derivatives showed a promising anti-inflammatory activity compared to ibuprofen. In this paper, we examine and discuss the structure-activity relationships and anti-inflammatory activities of these compounds.

Novel pyrrole derivatives and pyrrolo[2,3‐d]pyrimidine derivatives are synthesized and some of them are tested for their in vivo antiinflammatory activity.