Aim: This study investigated the relationship between Triglyceride Glucose, Neutrophil Lymphocyte Ratio, and gonarthrosis disease to investigate the role of these indicators in developing gonarthrosis. Method: Our study retrospectively investigated 141 patients aged between 50-84 years old who underwent follow-up in our orthopedic clinic between 01.06.2022-01.10.2021. The participants were divided into two control and study groups. Participants diagnosed with gonarthrosis were included in the study group, and healthy controls were included in the control group. Demographic characteristics of the patients and biochemical data were collected from patient files and electronic records. Results: The age of the patients was 54±12.5 (18-75) years. Among the biochemical parameters in our study, in cases with fasting gallstones, plasma glucose is 124.6 ± 24.5 mg/dL, triglyceride 198.3 ± 36.8 mg/dL, insulin 16.5 ± 5.6 uIU/mL, HOMA-IR 4 The level of .8±1.2 was statistically significantly higher in all of them compared to the control group (p=0.001). TGYI shows a significant difference according to the group (p