A haemoglobin (Hb) disorder was the first polymorphism suggested to have a relationship with malaria, as Hb S and C offer a survival advantage in malarial endemic regions. Two schoolgirls aged 11 and 16 were admitted to the Military Hospital in Omdurman on the 2 nd of April 2009. They had Hb (haemoglobin) SC and their parents were carriers of abnormal Hb; the mother was (HbAS) and father (HbAC). These girls were the first reported cases of HbSC in Sudan. Capillary Electrophoresis (CE) was initially used to determine the Hb type. CE-High Performance Liquid Chromatography (CE-HPLC) was used as a confirmatory test. A new type of abnormal Hb in Sudan is not unexpected, because is of its wide tribal diversity. Additionally, Sudan is a high malarial region and a new Hb variant is likely to be discovered.