PurposeTo assess the relationship between De Ritis (aspartate aminotransaminase [AST]/Alanine aminotransaminase [ALT]) ratio and pathological variables and whether it is an independent prognostic factor.Materials and MethodsWe analyzed 298 consecutive patients who underwent radical or partial nephrectomy for non-metastatic renal cell carcinoma (RCC) between 2006 and 2015. The association between De Ritis ratio and pathological variables including tumor size, presence of renal vein invasion, vena cava invasion, renal capsule infiltration, Gerota fascia invasion, renal sinus involvement, renal pelvic invasion, angiolymphatic invasion, adrenal gland involvement, lymph node involvement, tumor necrosis, and Fuhrman's grade was tested. Multivariable Cox analysis was performed to evaluate the impact of this ratio on overall survival and cancer-specific survival.ResultsAn increased preoperative De Ritis ratio was significantly associated with renal vein invasion, renal capsule infiltration and renal pelvis involvement (p<0.05) in non-metastatic RCC. On multivariate analysis we found that tumor size, Fuhrman grade and lymph node involvement were independent prognostic factors for cancer-specific survival. AST/ALT ratio had no influence on the risk of overall and cancer-specific survival.ConclusionAn increased preoperative AST/ALT ratio had a significant association with renal vein invasion, renal capsule infiltration and renal pelvis involvement in patients with non-metastatic RCC. However, it does not appear to be an independent prognostic marker in non-metastatic RCC.

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I n d e x e d i n P u b M e d , W e b o f S c i e n c e a n d S c o p u s Pankaj M. Joshi and Sanjay B. Kulkarni. A new technique of double-face buccal graft urethroplasty for female urethral strictures.

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Objective: We aimed to investigate the prognostic significance of the preoperative platelet-to-lymphocyte ratio (PLR) in a cohort of clinically non-metastatic renal cell carcinoma (RCC). Material and Methods (HR, 3.460; 95% CI, p=0.001 Amaç: Operasyon öncesi trombosit/lenfosit oranı (TLO)'nın klinik non-metastatik renal hücreli kanser (RHK)'de prognostik öneminin araştırılması planlandı. Gereç ve Yöntem: RHK nedeniyle 2006 ve 2015 yılları arasında radikal veya parsiyel nefrektomi geçiren 298 hastanın retrospektif analizi yapıldı. TLO için optimal kestirim değeri "receiver operating curve" (ROC) analizi ile hesaplandı. TLO'nun prognostik önemi; Kaplan-Meier eğrileri, tek değişkenli ve çok değişkenli Cox regresyon modelleri ile değerlendirildi.Bulgular: TLO için ROC analizi ile optimal kestirim noktası 200 (AUC=0.715; sensitivite, %52,4; spesifite, %90,6) (HR,3,460; 95% CI,1, p=0,001