Monkeypox is a zoonotic infection that causes painful or pruritic dermatologic lesions on the face, trunk, limbs, genitals, and mucosal surfaces. Monkeypox cases increased exponentially in 2022, prompting the World Health Organization and the United States Department of Health and Human Services to proclaim it a public health emergency. The role of community health nurses towards monkeypox prevention and control in transmission. We searched various databases like World Health Organization (WHO), Centers for Disease Control and Prevention (CDC), American Nurses Association (ANA), EMBASE, Web of Science, CINAHL, PubMed, and Cochrane databases were comprehensively searched. This review article focuses on the monkeypox pandemic, the transmission of the infection, vaccination and the role of healthcare workers. The healthcare role is crucial in preventing and promoting the monkeypox pandemic. These results can be consolidated when policymakers plan to increase the implementation of the healthcare worker in the face of monkeypox and future global threats.