It is estimated that road traffic crashes account for the death of about 1.25 million people each year, and it is the leading cause of death among youth between ages 15-29 years (WHO, 2016). Low and middle-income countries have about half of the world's vehicle, and yet account for 90% of the world's fatal accidents (WHO, 2016). Among the key risk factors for road accidents are speed, drink-driving, motorcycle helmets, seat-belts and child restraints, distracted driving (WHO, 2016). Tires maintenance or factors relating to the tire were not identified as risk factors by WHO. However, in Nigeria, it was estimated that between the years 2011 and 2015, tire bursts accounted for 7.8% of total causes of traffic crash in Nigeria (FRSC, 2016).Objective: This research aims to assess whether private vehicle drivers have better tire safety knowledge than commercial vehicle drivers in Nigeria. Methodology: The research employed a cross sectional study design on 454 motor vehicle drivers (commercial vehicle drivers n=233 and private vehicle drivers n=221). A simple, well-structuredquestionnaire was applied to them and data collected. Data analysis: The result was analyzed using Statistical Package for Social Sciences (SPSS).Result: The result showed an evidence supporting a relationship between driver's category and possession of tire safety knowledge. We conclude therefore that private vehicle drivers in Nigeria are more likely to have adequate tire safety knowledge than commercial vehicle drivers.