During an 11-month period, in a 1969 to 1970 photofluorographic survey for bullous disease of the lu,ng in adults 25 years or older, 59 men with the disease were found among 23,356 men, a rate of 2.5 per 1,000. Only one case was found among 21,531 women. The rates were higher in those over 44-years-old than in those between 25 and 44; they were higher in nonwhite than in white men.When the estimated rates for smoking and occupational exposure were calculated from data obtained by interview of approximately a 5% sample of this population, not a single case of bullous disease was found in a nonsmoker, and the rates were higher in those exposed to hazardous materials at work, particularly if the worker recalled respiratory symptoms during this exposure.