Approximately 19.3 million new cases of cancer and 10.0 million deaths from cancer were registered worldwide in 2020 (Hyuna, et al. 2020). According to WHO [1], cancer is the sixth leading cause of death globally. GLOBACAN [2] predicts that in 2040, new cases if cancers would have risen to 28.4 million. Cancer cell development is a multifaceted process that involves genetic mutation of normal cells and physiological changes that affect the body's defence mechanism [3]. The transformation of normal cells into cancerous cells necessitates the sequential acquisition of mutations resulting from genome damage caused by DNA replication errors, chemical instability of DNA bases, or attack by oxidative species and other free radicals generated during metabolic processes [4].
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