HighlightsVoltage-gated calcium channel classification—genes and proteins.Genetic analysis of neuropsychiatric syndromes.Calcium channel genes identified from GWA studies of psychiatric disorders.Rare mutations in calcium channel genes in psychiatric disorders.Pathophysiological sequelae of CACNA1C mutations and polymorphisms.Monogenic disorders resulting from harmful mutations in other voltage-gated calcium channel genes.Changes in calcium channel gene expression in disease.Involvement of voltage-gated calcium channels in early brain development.