Optimization of drug delivery through human skin is important in modern therapy. With limitations of oral drug delivery, pain and needle phobias associated with traditional injections drug delivery research has focused on transdermal delivery route. A new approach to transdermal delivery that acts as a bridge between the user friendless of patches and the broad effectiveness of hypodermic needles has recently received attention.by using needles of micron dimensions, termed microneedles, skin can be pierced to effectively deliver the drugs, The mechanism of action is based on temporary mechanical disruption of skin. The drug, in the form of biomolecules, is encapsulated within the micro needles, which are then inserted into the skin in the same way a drug like nitroglycerine is released into the bloodstream from a patch. The needles dissolve within minutes, releasing the trapped cargo at the intended delivery site. The present review focus on various studies related to micro needles for transdermal drug delivery and technology applications in various fields.