This study was aimed at exploring the roles of self-efficacy and an Employee Assistance Program (EAP) in employee burnout associated with stress. A total of 600 questionnaires were sent and 205 were collected from employees in high-tech industries in a Science Park in Taiwan. The valid collection rate was 34.2%. Path analysis was used to test the model. The results show that stressors can negatively and indirectly influence burnout through self-efficacy. This finding means that companies trying to reduce employee burnout should pay much more attention to enhancement of employee self-efficacy. Implications for application and future research are discussed.