Abbreviations: GABA, gama amino butyric acid; MAOI, mono amino oxidase inhibitor's; ODA, octa denoic acid; SSRI, selective serotonin reuptake inhibitors; TG, triglyceride AbstractTomato is an excellent fruit and can make people healthier reducing the risk of many diseases such as cardiovascular diseases, obesity, osteoporosis and cancer. The aim of the study is to evaluate the anxiolytic activity of tomato juice in animal model. Lycopene, present in tomatoes is thought to possess anxiolytic activity.Albino wistar mice were divided in three groups. Group I was considered as control group and given distill water. Group II was given low dose of tomato juice i.e. 10ml/ kg, group III received high dose of tomato juice i.e., 30ml/kg. All animals were given ad libitum diet and follow standard guidelines. The anxiolytic activity were evaluated with help of different models of anxiety such as head dip, open field, elevated plus maze and cage crossing apparatus. Our results showed positive anxiolytic effects. We concluded that tomato juice possesses positive anxiolytic effects due to presence of lycopene.

Objective: To assess long term outcomes of CT Angiography in low to intermediate risk patients of suspected ACS and to assess if CT-angiography is a safe modality to discharge patients with clinically non-significant coronary artery disease. Study Design: Descriptive cross-sectional study Place and Duration of Study: Tertiary Cardiac Center in Rawalpindi, from Dec 2021 to Apr, 2022. Methodology: A total of (n=600) patients who presented with ischemic sounding chest pain and suspicion of acute coronary syndrome (ACS) were selected via consecutive sampling technique and were followed up to 5-months. Patients' demographics, CT-Angiography findings and their outcomes were noted on data collection sheet. Data was analyzed by SPSS version-23. Descriptive statistics were run to present categorical data in frequencies and percentages. Chi-square and Fisher Exact Test was applied to find the association between study variables at 95% CI and 5% margin of error (α=5%). Results: Out of (n=600) suspected cases of acute coronary syndrome (ACS), n=352 (58.7%) were males and n=248 (42.3%) were females. As a result of follow-up of the ptaients, cases that represented in emergency department, readmission cases and revascularized cases were (n=10,4, 1;1.7%, 0.7%, & 0.2%) respectively. Frequency of ACS and STEMI patient was 0.0%. Mortality rate was 0.0%. There was significant association of comorbids with CT-angiography findings and the findings with outcome variables (p<0.05) except revascularization (p>0.05). Conclusion: In low to intermediate risk patients of suspected ACS, discharge decision from emergency department based on CT-angiography findings is safe and shows excellent long-term outcomes with no major adverse cardiac event (MACE) on long-term follow-up.