Objectives: The study aims to investigate the knowledge, attitudes, and practices of healthcare professionals towards coronavirus infectious disease 2019. In addition, to assess the factors influencing compliance of HCPs with infection control precautions (ICPs) towards COVID-19. Study Design: A descriptive correlational design was used to investigate factors influencing compliance to the novel coronavirus (COVID-19) infection control precautions. Methods: A Web-based survey instrument was used to obtain responses from convenient sample of healthcare professionals who are Jordanian nationality during the month of January 2021. Results: A total of 2147 healthcare professionals participated in this study, of which 1527 completed the study questionnaire. The results revealed that there were positive correlations between Healthcare professionals' compliance toward COVID-19 infection control precaution and knowledge, perception, age, and years of experience. In addition, a multivariate analysis model proved that the age, knowledge, and perception accounted for significant predictors of the compliance towards COVID-19 ICPs. Conclusions: Healthcare professionals demonstrated a high level of compliance with infection control precautions that minimizes the risk of COVID-19.

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