A 63-year-old man with hypertension was prescribed amlodipine for blood pressure Three days after initiating treatment, he developed an extremely pruritic rash on his back. Two steroid injections were administered at an urgent care clinic 1 day apart, and the patient was started on methylprednisolone. He experienced little improvement of his symptoms and was referred by his primary care physician for further allergy evaluation, where he presented to our clinic.The patient had been living by himself, denied use of new soaps or detergents, denied use of lotions or creams, and denied any other recent skin lesions, atopic symptoms, or urticaria. At the time of onset of the rash, the patient had taken levothyroxine, pravastatin, omeprazole, metoprolol, and amlodipine.

A 40-year-old male presented with itchy small nodules over the thigh, scrotum and pubic area of gradual onset and progressive course of 9 months duration. Histopathologic examination revealed horn filled crater with lip like projection at the side of the crater.