The current study was carried in physiology and pharmacology department at college of veterinary medicine, Al-Qadiysia University. The aim of this study was clarified the effect of Coenzyme Q10 in improvement of reproductive efficiency in male Wister rats after exposed to oxidative stress by lead acetate.40 male rats at 60 days old with 135±11gm in weight were divided into four equal groups, The first group was given distilled water with orally gavage for 60 days as control group (C).The second group (T1)wasgiven CoQ10 (200mg/kg/b.w)for 60 days , while the third group (T2) given lead acetate (10mg/kg/b.w) for 60 days. The forth(T4) group was gives lead acetate (10mg/kg/b.w) for 30 days then given CoQ10 for 30 days. At 60 days of experiment all animals were sacrified, sample of testis taken for measure the gene expression of(CYP17 and CPY11), gene expression results were revealed that there is up regulation (p≤0.05) in T1 compared with T2.