Modern systems are designed to have various non-functional attributes such as fault tolerance, robustness, et cetera. The ability of systems to adapt while being connected to a global network as in Cyber Physical Systems, presents new opportunities. Extra-functional qualities may be extended to nodes in the network that initially were devoid of them. It is inevitable that such vast global networks will consist of computationally constrained units. Extending such computationally constrained nodes with the ability to adapt is already a difficult challenge, which becomes more difficult when added with the constraint of timely behavior. In this chapter, the authors present an approach to tackle the issue of runtime adaptation on computationally constrained systems with real-time constraints. The focus is on systems with only a single general purpose processor, with the responsibility to run the system and application software. The authors introduce their framework towards this aim, followed by the architecture and a case study.