General structure of enol form of 1,3-diones 1,3-Dione metal complexes are used as catalyst in reaction of olefin oxidation and epoxidation [11,12]. Europium(III)-diketonates have excellent luminescent property [13]. It is also used as chelating agent [14] and extractants for lanthanide ions [15]. 1-(5-Bromo-2-hydroxyphenyl)-3-(thiophen-2-yl)-propane-1,3-dione and its metal complexes has been synthesized. The functionalized 1,3-dione potentially acts as bidentate ligand and coordinate with the transition metal ions through β-diketo system. The synthesized diketone and their transition metal complexes have been screened for in vitro antibacterial and antifungal activity using Resazurin 96 well plate method. The transition metal complexes showed moderate to excellent antimicrobial activity against all tested bacteria and fungi which constitutes a new group of compounds that can be used as potential metal derived drugs.

A new ligand 1-(5-bromo-2-hydroxyphenyl)-3-(4-bromophenyl)-propane-1, 3-dione have been synthesized from 5bromo-2-hydroxyacetophenone and 4-bromo benzoic acid. Their transition metal complexes have been synthesized. 1, 3-dione or ligand co-ordinate with the transition metal ions through oxygen atoms. The stiochimetry ratio ligand to metal has been 2:1. The synthesized 1,3-dione and their transition metal complexes have been characterized by 1 H-NMR, 13 C-NMR,IR, Elemental analysis, Powder XRD, TGA. Solution conductivity, Magnetic susceptibility and Antimicrobial screenings were also studied using Resazurin 96 well plate method. Tetracycline and Amphotericin B are used as standard drugs. The transition metal complexes showed moderate to excellent antimicrobial activity against all tested bacteria and fungi.