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INTRODUCTION Breast cancer is the most common malignancy and the second leading cause of cancer-related death after lung cancer among women in the United States and Europe. Due to major advances in screening and early diagnostic procedures, most breast cancer patients are diagnosed at an early stage. However, 6% to 10% of patients still present with metastatic breast cancer at the time of diagnosis; for those patients, relapses tend to occur earlier and survival rates are shortened. AIMS AND OBJECTIVES To study MMP 9, Estrogen receptor, Progesterone receptor and Her-2-Neu expression in breast carcinoma by immune histochemistry. Compare MMP 9 expression with result of Estrogen receptor expression, Progesterone receptor expression and Her-2-Neu expression in breast carcinoma. To study MMP 9 expression in relation to staging and grading of breast cancer. MATERIALS AND METHOD This cross-sectional study was conducted on a group of patients admitted in Department of General Surgery, R G Kar Medical College & Hospital, Kolkata from January 2018 - Jun 2019. Approval from an institutional review board was obtained at the initiation of the study. All patients were provided with signed informed written consent. Cross sectional, descriptive and observational. RESULTS AND PUBLICATION From the above table it is evident that only 2 of the patients with stage II tumor showed MMP9 positivity while 8 were negative, but in case of patients with stage III disease 20 out of 22 showed MMP9 positivity with only 2 of them showing a negative MMP9 pattern. From the above table it is evident that only 1 out of 6 cases with grade 1 breast cancer was positive for MMP9 , while 11 out of 16 cases of grade 2 disease showed MMP9 positivity and all cases with grade 3 was found to be MMP9 positive. The above table clearly shows that out of 12 ER positive breast cancer cases only one third i.e. 4 were MMP9 positive. However, out of 20 ER negative cases 90% i.e. 18 were found to be MMP9 positive.

The diagnosis of renal cortical abscess can be missed as the condition is frequently associated with blood and urine culture negativity. Moreover, imaging by ultrasonography in the early stages of the disease may miss small or developing abscesses and carbuncles. Renal abscesses being more common in the immunosuppressed, the condition may be overlooked in the immunocompetent. We report a case of bilateral renal cortical abscesses in an immunocompetent individual who presented to us with Pyrexia of Unknown Origin (PUO). The patient's urine and blood culture were negative and initial ultrasonography of the abdomen revealed no abnormality. Based on clinical suspicion a repeat ultrasonography was done, which detected bilateral renal cortical abscesses. Thus, when in doubt repeat or more sensitive imaging is required for correct diagnosis. Important differences exist between renal cortical and cortico-medullary abscesses and this awareness guides therapeutic decision. Missing a renal cortical abscess based on single negative imaging could be catastrophic.

INTRODUCTION Breast cancer is a worldwide malignant disease. Over one million new cases of breast cancer are diagnosed every year. Cancer of Breast ,the most prevalent cancers in the developing country like India, is the highest registry of cancer among Indian women and important cause of morbidity and mortality ABO Blood Groups also has been associated with risk and survival of several malignancies, including pancreas cancer and stomach cancer, the mechanism is complex and yet unclear. AIMS AND OBJECTIVE To study histo-pathological type and grades of Breast Carcinoma. To find out ABO and Rh antigen expression in blood (ABO Blood Group) of respective Breast Carcinoma patients. To assess association between ABO Blood Groups and Breast Carcinoma. MATERIAL AND METHODS It is an Observational, Descriptive and Cross sectional study. The study will be carried out in the Department of Pathology with collaboration of Department of General Surgery, Blood Bank and Record Section of R.G. Kar Medical College and Hospital, Kolkata, over a period of 18 months. Over a period of 18 months. (After ethics committee clearance and acceptance from the West Bengal University of Health Sciences) sample size 114. RESULT AND ANALYSIS Among 114 cases, 18 were of Grade 1 while Grade II and Grade III comprised 46 and 50 cases respectively.18 Grade I cases, 72.2% (n=13) were Invasive Breast Carcinoma and 27.8% (n=5) were Lobular Carcinoma cases. Among 46 Grade II cases, 82.6% (n=38) were Invasive Breast Carcinoma, 10.9% (n=5) were Lobular Carcinoma, 4.3% (n=2) were Medullary Carcinoma and 2.2% (n=1) were Metaplastic Carcinoma cases and in 50 Grade III cases, 90% (n=45) were Invasive Breast Carcinoma, 8% (n=4) were Lobular Carcinoma and 2% (n=1) were Pleomorphic Carcinoma cases.

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