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Although oral human herpesvirus 1 (HHV-1) affects approximately 75% of the general population, recurrent infections are more often encountered in immunocompromised patients. Such infections become a serious concern, especially following allogeneic bone marrow transplantation (BMT), as the lesions are more extensive, aggressive, slow-healing, and painful in comparison with those in healthy indi-to be effective and safe in the management of recurrent herpes labialis in patients with chronic GVHD; however, more studies are necessary.