Addressing the aspect of unused drug disposition constitutes a challenge for Mexican government, due to health implications related to inadequate disposition. No matter how efficient the programs of collection and disposal of expired drugs are, none of them can collect all unused or expired drugs, that is the reason why the best approach might be to prevent this need.

A matrix system was developed that releases ibuprofen (IB) over a 12-hour period and the influence of the polymer type and concentration on the release rate of the drug was evaluated. Tablets containing different concentrations of Carbopol (CP), hydroxypropyl methylcellulose (HPMC), or ethyl cellulose (EC) were prepared using direct compression and the drug content, content uniformity, hardness, friability, dissolution performance, and in vitro release kinetics were examined. Formulated tablets were found to be within acceptable limits for physical and chemical parameters. The release kinetics of the Carbopol®971P 8% formulation showed the best linearity (r 2 =0.977) in fitting zero-order kinetics, suggesting the release rate was time independent. The drug release from tablets containing 8% CP was extended over approximately 18 hours and the release kinetics were nearly linear, suggesting that this system has the potential to maintain constant plasma drug concentrations over 12 hours, which could reduce the frequency of administration and the occurrence of adverse effects associated with repeated administration of conventional IB tablets.Uniterms: Ibuprofen/study. Ibuprofen/sustained release tablets. Ibuprofen/formulation/carbopol. Ibuprofen/formulation/hydroxypropyl methylcellulose. Ibuprofen/formulations/ethyl cellulose. Ibuprofen/ formulations/release kinetics.

No abstract

NOR:HPβCD:GA was the best approach for improving the bioavailability of NOR.

The community pharmacy is an excellent place to identify those with undiagnosed diseases and refer them to their health professionals for treatment and continuing care. However the process of implementation of campaigns and activities to this end in community pharmacy has been slow and implemented by a pharmaceutical minority. It is crucial understand what are the barriers to participation, in order to design enabling actions to achieve greater adherence of pharmacists in these activities.In order to identify and analyze the elements that hinder the dissemination, implementation and sustainability of pharmaceutical services aimed at the promotion and prevention, in the Argentine community pharmacies, a participatory diagnosis workshop was designed.Although pharmacists stressed that the absence of such professional activities entails a deterioration of pharmacists' image recognition in society, they expressed lack of constancy, economic incentive, specific training in the subject, time and physical space as own barriers to implementation thereof. Pharmacists think that these limitations are generally not taken into account when designing or planning campaigns.The university, must encourage interaction and involvement of different actors (patients, caregivers, family, health professionals) in order to engage them in solving the issues together and that they design activities according to local characteristics, to create actions and benefits that can be sustained in the long term.