Carriers of both GCK and HNF1A mutations manifested a typical MODY 3 phenotype and showed that the presence of a second mutation in the GCK gene apparently did not modify the clinical outcome, at least at the time of this study. Our data show that co-inheritance of MODY 2 and MODY 3 mutations should be considered, at least in some cases, for accurate genetic testing.

No abstract

There are no studies that have specifically assessed the role of intravenous lipid emulsions (ILE) enriched with fish oil in people with diabetes receiving total parenteral nutrition (TPN). The objective of this study was to assess the metabolic control (glycemic and lipid) and in-hospital complications that occurred in non-critically ill inpatients with TPN and type 2 diabetes with regard to the use of fish oil emulsions compared with other ILEs. We performed a post-hoc analysis of the Insulin in Parenteral Nutrition (INSUPAR) trial that included patients who started with TPN for any cause and that would predictably continue with TPN for at least five days. The study included 161 patients who started with TPN for any cause. There were 80 patients (49.7%) on fish oil enriched ILEs and 81 patients (50.3%) on other ILEs. We found significant decreases in triglyceride levels in the fish oil group compared to the other patients. We did not find any differences in glucose metabolic control: mean capillary glucose, glycemic variability, and insulin dose, except in the number of mild hypoglycemic events that was significantly higher in the fish oil group. We did not observe any differences in other metabolic, liver or infectious complications, in-hospital length of stay or mortality.

No abstract

Mujer de 61 años remitida a la consulta de Endocrinología para estudio de episodios de mareo sin giro de objetos, así como nerviosismo, palpitaciones y temblor que mejoraban tras la ingesta de hidratos de carbono. Con la sospecha clínica de hipoglucemias y tras la realización de pruebas complementarias, la paciente fue diagnosticada de hiperinsulinismo endógeno. Se descartó la presencia la presencia de hipoglucemias facticias. Se llevó a cabo una ultrasonografía endoscópica gracias a la cual se diagnóstico un insulinoma pancreático no visible en la tomografía computerizada. Finalmente se realizó una enucleación de la lesión tras la que se produjo la resolución del cuadro clínico. La paciente permanece asintomática en el momento actual.