We report two siblings with Netherton's syndrome who developed hypernatraemia during the neonatal period. Although this is likely to have been due to trans-epidermal water loss in erythrodermic infants rather than to Netherton's syndrome specifically, this complication should be remembered in erythrodermic infants as a preventable cause of neonatal morbidity.

To study antibody binding in cutaneous lupus, we used human skin grafted onto nude mice. By immunofluorescence examination, mice injected with anti-Ro (SS-A) sera from subacute cutaneous or neonatal lupus erythematosus patients showed evidence of human IgG deposited in the skin, while mice injected with anti-native DNA or normal sera did not. We present evidence that there is specific binding of anti-Ro ~

We followed three children who met the clinical, histologic, and immunologic criteria for chronic bullous disease of childhood (linear IgA dermatosis). All patients were able to discontinue therapy after two months to two years. Two have continued to experience transient mild episodes of blistering that have not required reinstitution of systemic therapy. In our opinion, children with this condition have a benign course with disease-free remissions and can be expected to discontinue all therapy eventually.