Purpose:To compare the biocompatibility of ethyl-cyanoacrylate (ECA) and octylcyanoacrylate (OCA) wound closures to sutures in rat skin. Methods: Twenty-four male Wistar rats were subjected to three incisions which were closed using ECA, OCA or sutures . Rats were divided into four groups which received biopsies on the 3 rd , 7 th , 14 th or 21 st postoperative days. Necrosis, inflammation, dermatitis, infection, dehiscence, cicatricial enlargement and costs were examined; the histopathology evaluated was epithelialization, deep openings, foreign substance reaction, residues of synthesis material, fibrosis, inflammation, dehiscence and necrosis. Results: The tissue adhesives presented the largest dehiscence levels, and ECA the lowest cost while the other measures were similar. Regarding histopathology, deep openings were more common with OCA and granulomas were most frequently obtained with ECA. The two tissue adhesives produces less inflammation than the inicial suture from post-operative day 7, while ECA and OCA cause similar inflammatory reactions. ECA did not differ significantly from OCA and sutures on other measures. Conclusion: ECA was well tolerated in this study and did not induce necrosis, allergic reactions or infections, presenting several advantages in relation to OCA and sutures, including lower costs and fewer complications. Key words: Tissue adhesives. Cyanoacrylates. Materials Testing. Rats. RESUMOObjetivo: Investigar a biocompatibilidade do etil-cianoacrilato (ECA) em fechamento de pele em ratos comparativamente ao octil-cianoacrilato (OCA) e à sutura. Métodos: Rattus norvegicus albinus (n=24) foram submetidos a três incisões, cada uma fechada por um dos métodos de síntese estudados. Quatro grupos (n=6) foram feitos, conforme o dia pós-operatório (DPO) em que foram eutanasiados: 3DPO, 7DPO,14DPO e 21DPO. Necrose, edema, eritema, dermatite, infecção, deiscência, alargamento cicatricial e custos foram os itens examinados; histopatologicamente avaliou-se epitelização, abertura profunda, reação de corpo estranho, resíduos de material de síntese, fibrose, reação inflamatória, deiscência e necrose. Resultados: Os adesivos apresentaram os maiores níveis de deiscências, e o ECA o custo mais baixo; nos demais itens, não houve diferenças. Histopatologia: A abertura profunda foi mais comum com o OCA; ECA foi o material mais encontrado em granulomas; os adesivos foram mais brandos que a sutura a partir do 7º DPO no quesito inflamação, enquanto que o ECA causou uma reação similar ao OCA; nos outros itens, ECA não apresentou diferença importante em relação ao OCA e à sutura. Conclusão: O ECA foi bem tolerado neste grupo de estudo, sem induzir necrose, reações alérgicas e infecção, apresentando diversas vantagens de uso em relação ao OCA e à sutura. Descritores: Adesivos Teciduais. Cianoacrilatos. Teste de Materiais. Ratos. -ORIGINAL ARTICLE Souza SC et al 310
Objective Evaluation of the frequency of the relative positions and length of vermiform appendix in a group of corpses examined by the authors. Method Dissection of 377 adult cadavers autopsied. Results and conclusions Retrocecal: 43.5%; subcecal: 24.4% post-ileal: 14.3%, pelvic: 9.3%; paracecal: 5.8%; and pre-ileal appendices: 2.4%, other positions: 0.27%, mean length: 11.4 cm.
BACKGROUND: The advantages of the cyanoacrylates in cutaneous synthesis have been often demonstrated in the literature. However, these products have been underutilized in Brazil due to the high costs of the 2-octil-cyanoacrylate. Besides, few studies have been done with the more economically accessible form, the 2-etil-cyanoacrylate, as a cutaneous tissue adhesive. OBJECTIVE: To evaluate the effectiveness of the closing of cutaneous lesions using ECA. METHOD: This was a prospective study in which 46 wounds were occluded using the low cost ECA as an alternative to intradermal suture. RESULTS: Excisions (97,8%) and traumatic wounds (2,2%) were treated with 2-etil-cyanoacrylate and deep relaxed sutures as synthesis method. Unaesthetic scars (22%), infection (2,1%), dehiscence (2,1%) and contact allergic dermatitis (2,1%) were the problems we found. There were no cases of necrosis or keloids. The results were considered satisfactory in most cases (97,3%). CONCLUSIONS: The use of 2-etil-cyanoacrylate was shown to be safe and with satisfactory cosmetic results in this group of patients. Keywords: Cyanoacrylates; Suture techniques; Tissue adhesives Resumo: FUNDAMENTOS: As vantagens dos cianoacrilatos em síntese cutânea têm sido sobejamente mostradas na literatura. Entretanto, estes produtos têm sido subutilizados no Brazil devido aos elevados custos do 2-octilcianoacrilato. Ademais, a forma mais economicamente acessível, o 2-etilcianoacrilato, tem sido pouco estudada como adesivo cutâneo. OBJETIVO: Avaliação da eficácia do fechamento de lesões cutâneas usando o 2-etilcianoacrilato. MÉTODO: Estudo prospectivo no qual 46 feridas foram ocluídas usando o 2-etilcianoacrilato de baixo custo como alternativa a sutura intradérmica. RESULTADOS: Feridas excisionais (97,8%) e traumática (2,2%) foram tratadas com 2-etilcianoacrilato e suturas profundas relaxadoras como método de síntese. Cicatrizes inestéticas (22%), infecção (2,1%), deiscência (2,1%) e dermatite alér-gica de contato (2,1%) foram os problemas encontrados. Não houve casos de necrose ou quelóides. Os resultados foram considerados satisfatórios na grande maioria dos casos (97,3%). Conclusões: O uso do ECA mostrou-se seguro e com resultados cosméticos satisfatórios neste grupo de pacientes.
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mso-font-signature:-1610611985 1107304683 0 0 415 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif"; mso-fareast-font-family:"Times New Roman";} .MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-size:10.0pt; mso-ansi-font-size:10.0pt; mso-bidi-font-size:10.0pt;} @page WordSection1 {size:612.0pt 792.0pt; margin:70.85pt 3.0cm 70.85pt 3.0cm; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.WordSection1 {page:WordSection1;} --> <!--[if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabela normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} </style> <![endif]--> <p class="MsoNormal" style="text-align: justify;"><span style="font-size: 12pt;">A Anatomia, ramo da Biologia que trata da forma e da estrutura dos seres organizados, teve origens obscuras e lento desenvolvimento. Sendo o mais antigo ramo da Medicina, a Anatomia é o conjunto de conhecimentos relacionados à saúde que mais tem sido influenciado pela história. Personagens brilhantes permeiam a evolução desta ciência. Vê-se a influência da religião durante a Idade Média ao retardar o avanço da Medicina e das ciências em geral e a contribuição de artistas do Renascimento ao tentar retratar a forma perfeita do corpo humano. As técnicas rudimentares de outrora contrastam com as modernas tecnologias, as quais têm auxiliado a corrigir conceitos errôneos do passado. Atualmente a fragmentação da Anatomia tem comprometido sua utilidade; entretanto, desde as primeiras dissecações em animais até o advento da internet, paira a certeza de que não há Medicina sem Anatomia.</span></p>
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