Telmisartan (TMS), an antihypertensive drug, is classified as class II according to Biopharmaceutical Classification System (BCS) with low solubility and high permeability. The purpose of this study was to prepare and characterize solid dispersion of TMS with hidroxypropyl methyl cellulose (HPMC) E5 LV to increase the solubility. Solid dispersion was prepared in three different ratio TMS:HPMC 2:1, 1:1, and 1:2 (w/w) by co-grinding method for 60 minutes. Solubility test was conducted in distilled water for 72 hours and the amount of TMS was determined by spectrophotometry UV. Result of Powder X-Ray Diffraction (PXRD) showed a decrease in intensity of TMS in accordance with the amount of HPMC E5 LV in solid dispersion. Fourier Transform Infra-Red(FT-IR)Spectra showed no significant shift of wavelength. Scanning Electron Microscopy (SEM) result presented the crystalline form of TMS, while both physical mixture and solid dispersion at different ratio showed TMS stick on the surface of HPMC E5 LV. Thermogram of Differential Scanning Calorimetry (DSC) showed an incline of endotherm peak as the ratio HPMC E5 LV increased. The solubility result of intact TMS was 0.49±0.03µg/mL, while the physical mixture and solid dispersion 2:1, 1;1 and 1:2 were 1.87±0.18 µg/mL, 5.36±0.48 µg/mL, 7.24±1.73µg/mL, and 14.89±1.49 µg/mL, respectively. In conclusion, solid dispersion of telmisartan-HPMC E5 LV enhanced the solubility of TMS.

Kedelai (Glycine max) diketahui mengandung berbagai nutrisi salah satunya vitamin B1 atau tiamin. Tiamin merupakan vitamin yang dibutuhkan untuk menimbulkan nafsu makan, membantu penggunaan karbohidrat dalam tubuh dan sangat berperan dalam sistem saraf. Pada penelitian ini dilakukan penetapan kadar vitamin B1 pada kacang kedelai dengan menggunakan metode kromatografi lapis tipis kinerja tinggi (KLTKT)-Densitometri. Sampel diekstraksi dengan menggunakan air suling 20 mL dan metanol 30 mL. Analisis dengan KLT menggunakan metanol: air: asam asetat: amoniak (5: 4,5: 0,5: 0,75) sebagai fase gerak dan silika gel 60 F254 sebagai fase diam. Hasil KLTKT menunjukkan bahwa sampel memiliki nilai Rf yang sama dengan pembanding (Rf = 0,5). Linearitas vitamin B1 diperoleh pada rentang konsentrasi 100-500 µg/mL dengan nilai koefisien korelasi 0,998 dan persamaan regresi y = 238,4 + 5,575x. Nilai simpangan baku 37,1724 µg/mL, batas deteksi 20,0031 µg/mL dan batas kuantitasi 66,677 µg/mL. Analisis kuantitatif menggunakan densitometri diperoleh kadar vitamin B1 sebesar 0,0599 ± 0,002363 %.