A palladium-catalyzed decarboxylative acylation of phenylacetamides with α-oxocarboxylic acids via C-H bond activation is described. This protocol provides efficient access to a range of ortho-acyl phenylacetamides, which can be easily converted to 3-isochromanone derivatives.

A palladium-catalyzed oxidative acylation of O-phenyl carbamates with a-oxocarboxylic acids via selective aromatic C À H bond activation is described. This protocol represents the first ortho-acylation of phenol derivatives, and a catalytic amount of triflic acid additive is crucial for this transformation.

The stereoselective amination of various chiral benzylic ethers using chlorosulfonyl isocyanate is developed, and the application of this method to the total synthesis of a potent antidepressant, (+)-sertraline, from readily available 1-naphthol is also described.

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