This study focuses on the techniques of improving refinery reliability, profitability, and availability. In this study, a corrosion control document (CCD) knowledge base system in crude oil distillation unit process is developed. CCD consists of numerous parts namely damage mechanisms (DM), design data, critical reliability variables (CRV), guidelines, etc. To develop CCD, first off, a material selection diagrams (MSD) is drawn. The DM of each process effecting equipments that are based on American Petroleum Institute 571 should be chosen. Operating variables affecting severity of DM are selected in the beginning stage of CRV. Finally, guidelines are provided for the reliability of equipments.

No abstract

The expression of GPR50 in CSLC and several breast cancer cell lines was assessed by RT-PCR and online platform (UALCAN, GEPIA, and R2 gene analysis). The role of GPR50 in driving CSLC, sphere formation, cell proliferation, and migration was performed using shGPR50 gene knockdown, and the role of GPR50-regulated signaling pathways was examined by Western blotting and Luciferase Assay. Herein, we confirmed that the expression of G protein-coupled receptor 50 (GPR50) in cancer stem-like cells (CSLC) is higher than that in other cancer cells. We examined that the knockdown of GPR50 in CSLC led to decreased cancer properties, such as sphere formation, cell proliferation, migration, and stemness. GPR50 silencing downregulates NF-kB signaling, which is involved in sphere formation and aggressiveness of CSLC. In addition, we demonstrated that GPR50 also regulates ADAM-17 activity by activating NOTCH signaling pathways through the AKT/SP1 axis in CSLC. Overall, we demonstrated a novel GPR50-mediated regulation of the NF-κB-Notch signaling pathway, which can provide insights into CSLC progression and prognosis, and NF-κB-NOTCH-based CSLC treatment strategies.