The aim of the research work is to evaluate the polyphenols and antioxidant activity of African grape fruits. The methanolic extract was evaluated for its phenolic contents using Folin-Ciocalteu reagent, antioxidant activity using 1, 1- diphenvi1-2 picrvlhidrazyl (DPPH) radical scavenging activity, and flavonoid using sodium nitrite solution. The total phenolic content was 380+2,11mg/100g gallic acid equivalent (GAE), antioxidant activity of 562.25 ± 2.91%, and flavonoids contents of 20.63 ± 1.80mg/100g quercetin equivalent (QE), The results indicated the importance of Lannea macrocarpa fruits as potential source of polyphenols which if property utilized could supplement the existing sources of antioxidants for the formulation of drugs and other therapeutic uses.