The material on registration of malformation has been studied in Bukhara region for 2010. Out of 159 infants, born with different intrauterine anomalies the 16.35% (26) were found with the cleft lip and palate in different variants. After the complex examination by specialists (surgeon, pediatrician, orthopedist, otolaryngologist, psychoneurologist) operative treatment was conducted depending on degree of the defect. The study of the condition of immune system in infants was conducted after operative treatment. The examined were divided into 2 groups-infants without postoperative complications and infants with postoperative complications. We studied the quantitative determination of lymphocytes with phenotype CD3, CD4, CD8, CD16, concentration IgG, IgA IgM, phagocytic activity of neutrophils and the level of CIA. It was found that in infants with congenital cleft lip and palate exist the deflections on the condition of immune system, which were more denominated in infants with postoperative complications.

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