Both metal-catalyzed and organocatalytic transfer hydrogenation reactions are widely employed for the reduction of C=O and C=N bonds. However, selective transfer hydrogenation reactions of C=C bonds remain challenging. Therefore, the...
Both metal-catalyzed and organocatalytic transfer hydrogenation reactions are widely employed for the reduction of C=C, C=O and C=N bonds. Described herein is an unconventional catalyst-free transfer hydrogenation reaction of activated al-kenes using isopropanol as an eco-friendly reductant and solvent. The reaction gives convenient synthetic access to a wide range of substituted malonic acid half oxyesters (SMAHOs) in moderate to good yields. Mechanistic investigations point to-wards an unprecedented hydrogen bond-assisted transfer hydrogenation process.
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