A 12 years old girl reported with a history of unsuccessful attempt at vaginoplasty. During admission, she was found to be in septic shock and detected to have pyoperitoneum as well as, involuntary leakage of urine. Exploratory laparotomy was carried out as the life saving measure. After 1 year, she was taken up for the repair of vesicovaginal fistula (VVF). She presented again with complaints of mass in lower abdomen after 8 months. When evaluated the mass was diagnosed as hematometra and blood was drained out, by syringing the uterus in a surgical procedure. Further she developed severe pain along with recurrence of the mass, which was progressively increasing in size. The repeat vaginoplasty was attempted but found unsuccessful, resulting in hysterectomy at 15 years. How to cite this article Pati T, Nayak S, Mohapatra S, Sahu MC, Padhy RN. Hysterectomy of a 15 Years Old Girl: A Rare Case Report. Donald School J Ultrasound Obstet Gynecol 2015;9(3):331-334.