No abstract

No abstract

A trial of omentoplasty was carried out on 20 patients with unilateral filarial lymphoedema to assess its role in the reduction of oedema volume after failed lymphonodo-venous shunt (LNVS) or as a primary procedure. Omentoplasty was done through a midline laparotomy. The omentum was mobilized from the colon, preserving both gastroepiploic vessels, and transferred to the thigh either through the lower end of the laparotomy incision or through a separate stab and placed subcutaneously in the upper third of the thigh. There was no operative mortality. Morbidity was mainly incisional hernia and superficial wound infection. Fourteen of 18 patients had more than 25% reduction in oedema volume during the immediate postoperative period, and 5 of the 18 had more than 50% reduction. However, there was a gradual loss of response with time. Age, gender, grade of lymphoedema, duration, and previous surgery did not influence the outcome. The incidence of incisional hernia could be reduced by transferring the omentum through the midline. There was a statistically significant reduction in postoperative adenolymphangitis attacks whether or not the oedema volume was reduced. In some patients the oedema was reduced sufficiently to permit subcutaneous excision of the lymphoedematous tissue. There appears to be a definite but limited role for omentoplasty in patients who have failed LNVS.

The most important and worldwide utilized nanomaterial is silver metal nanoparticle which after synthesis changed to colloidal or powdered form. After successful characterization different sizes of these particles measured if intermixed and confirmed to different size ranges. Different sizes segregates into various size groups. Specific small or large size silver in powder form also readily available in market for various applications and experiments after biological or herbal synthesis and characterization. 1 to 20 nm size ranges are grouped under inconsiderable or smaller size range whereas 20 to 100 nm size ranges or above sizes are grouped under considerable or bigger size range. Following serial oral ingestion for experiment, aqueous and magnetic stirred synthesized AgNps of less than 20 nm of null account size accumulate in mature and developing kidneys of pregnant Swiss Albino mice and their freshly born fetuses after passing through blood vessels of pregnant mice and after absorption from gastro intestinal tract and accumulate in mature kidney due to trap inside. These particles also crosses blood placental barrier reaches fetus body in womb and accumulate in developing kidney due to same mechanism. These particles also surprisingly execute sex specific corrosive manifestation. We have examined the corrosive and hazardous effect of 10 gestational days (5 to 15 gestational days) serial oral bolus ingestion of 2.75 to 18.5 nm size range AgNps colloidal solution in a lower dose of 0.35 (1), 0.55 (2) mg/kg. b.w, in an in between dose of 4 (3), 8 (4) mg/ kg. b.w. and in a higher dose of 12 (5) and 16 (6) mg/kg. b.w. treatment on mature and developing right and left kidneys of pregnant mice and fetuses. Groups were designated as 1(Control); 2, 3, 4, 5 and 6 (Treated). At lower dose we report negligible histological findings and at higher bolus dose we report marked histological findings. This particular size range group silver nano particles (AgNps) treatment turns into insignificant reduction in kidney weight and height at higher dose, with some hemorrhagic focuses along with histological alterations. Predominantly agenesis and severe atrophy of renal corpuscles, increase of urinary space, generalized anasarca of podocytes, degeneration and dysmorphology with congestion of proximal convoluted tubules and distal convoluted tubules, loss of brush border membranes and damage of squamous epithelium of loop of Henley with severe congestion in medullary rays and collecting ducts are observed in routine histology. The in between dose demonstrated in between results. These manifestations are found quite same to chronic and acute renal failure with hematuria. All these alterations, in prolong sustain, could land up to beginning of apoptosis and progress of cell necrosis in these vital organs.

No abstract