Mucormycosis is antifungal eye infection difficult to manage this infection with limited use of diagnostic tool and therapeutic option, but previous literature studied diagnostic strategies and evaluate the potency of antifungal agent as a treatment option. Mucormycosis was difficult to study on imaging studies. Surgery plus antifungal therapy of high dose yields greater survival rates. Mucorales are most widely resisted to the used as an antifungal agent. Amphotericin -B were kept for de-escalation refractory therapy whereas, patient’s intolerant to Amphotericin B. Keywords: Mucormycosis, amphotericin, antifungal agents

Today there are many antifungal drugs and their formulations like a tablet, capsule, cream, ointment, gel, soap etc are present in the market many of them are effective in treatment in minor or severe cases of fungal infection caused due to different fungal or yeast species. But there are many side effects or adverse effects that occur which makes them unpleasant. This challenges to drug developers to make drug or formulations which are effective in the treatment and have no or minimum side effects. This challenge makes our eyes focus on natural chemical constituents, which are known to be having fewer side effects with effective treatment of disease. Here we have taken two receptors from the RCSB PDB database which is a structural component of candida Albicans (1CZ1 and IAI9) proven to be the target of many antifungal drugs, both are responsible for different mode of action. The Anacyclus pyrethrum (L.) and Senna Obtusifolia (L.)  have many chemical constituents having different pharmacological activity like anti-inflammatory, anti-cancer, etc. from these two plant species some chemical constituents are selected depending on their structural characteristics. After selection ligand-receptor molecular docking (by using Autodock Vina) was carried out between them. For its verification of antifungal activity, it is then compared with selected Standard drugs which have already clinically proved as an antifungal drug. Sesamine from Anacyclus pyrethrum (L.) and Obtusifoline and Physcion from Senna Obtusifolia (L.) are potent lead compounds which on future structural modification gives us desired antifungal activity.

In the world of automation and industrial revolution it’s a need of industries that manual activities overtaken by machine activities. When it talks about automation, remind of industry 4.0 is a new production model where it focuses on interaction between human and machine which is also important to improve the means and efficiency of production. In this project it lightens such aspect of industry which may provide the advantages of improving productivity and quality while reducing processing time and increasing safety to the manufacturing process. The project demonstrates a simple automation in cleaning process that eliminates manual intervention for industrial chips cleaning. It is not only impacting the quality of process but also improved the quality of product simultaneously. In most of the process, it is used separate dedicated cleaning machines to achieve desired output, while it also impacts on power consumption as well as time consumed in cleaning of that component. Improvement of quality as well as productivity simultaneously under production have been reported in this paper. Improvement of workstation hygiene by reducing workstation noise which generated from high pressurise air by damping it to some extents have been also reported in this paper. These are the nobility things of this paper.