Pulsatile delivery helps in providing the drug at an exact moment based on the disease's pathophysiology that cause improved patient therapeutic efficacy. Drug release rapidly after specific lag time this are advantage for many diseases condition. This system is designed according the body's circadian rhythm and after a lag time, the medication is released fast and totally as a pulse. Pulsatile delivery systems helpful in disease include asthma, arthritis, attention deficient syndrome, peptic ulcer and hypercholesterolemia. These systems are useful for diseases with chrono pharmacological behavior that necessitate nighttime administration, medications with a high first pass effect or GIT site specific absorption, and drugs with a high risk of toxicity or tolerance. By reducing dosing frequency, these devices help increase patient compliance. The foundation for this article is the disease that treat by pulsatile delivery system with drug used for specific disease condition and chrono pharmacology of all disease that mention in article.