Total of one-hundred 1-day old broiler chicks were used for 21-days experimental period. Chicks were divided into 5-groups.G1; no treatment (control negative), G2; was inoculated with 0.1ml of (1×10 8 ) Salmonella entertidis (S. entertidis) at first day of age via crop gavage and kept as positive control., G3; was inoculated with 0.1ml of (1×10 8 ) S. entertidis at 1 st day of age via crop gavage and was treated with grapefruit peels extract 0.5mg/mL orally in drinking water from the second day till the seventh day of age., G4; was inoculated with 0.1ml of (1×10 8 ) S.entertidis at 1 st day of age via crop gavage and was treated with Panflor ® 1ml/L orally in drinking water from the second day till the seventh day of age.G5; was inoculated with 0.1 ml of (1×10 8 ) S. entertidis at 1 st day of age via crop gavage and was treated with a combination of grapefruit peels extract 0.5mg/ml and Panflor ® 1ml/L orally in drinking water from the second day till the seventh day of age. The growth performance was estimated. Serum samples were collected from each group at 10 th and 21 days of age for estimation of (ALT, AST, GGT, Urea, Creatinine and Lipase). The results showed that the treatment with grapefruit peels extract and/or antibiotic in groups 3, 4 and5 showed a substantial decrease in (ALT, AST, GGT and lipase activity) with the lower serum urea and creatinine concentrations compared to group 2 at 10 th and 21 days. It was concluded that grapefruit peels extract can be used in control S. entertidis in chicken.