Background and purpose of the studyThe aim of this study was to investigate the effect of cinnamaldehyde on mucositis and salivary total antioxidant capacity in gamma-irradiated rats.MethodsThe study was conducted on 28 male Wistar rats, 7–11 weeks of age and 160 ± 20 g body weight, divided into four groups of seven rats each. The first group receiving normal saline (S), the second group receiving saline and gamma radiation (SR), the third group receiving 50 mg/kg cinnamaldehyde 98% (C), and the fourth group receiving 50 mg/kg cinnamaldehyde 98% and gamma radiation (CR). SR and CR groups were exposed to 15 Gy gamma irradiation for 7 min and 39 s. Rats were intraperitoneally injected each day during the 10-day period of the experiment, and their tongues and lips were examined to assess the incidence and severity of mucositis. The saliva samples were taken from the animals three times on day zero, six, and ten.ResultsThe mean mucositis incidence appeared to be delayed in the CR than the SR group (P = 0.024), and the severity was significantly higher in the SR compared to the CR group;the difference was statistically significant on the second day (P = 0.027). In the evaluation of salivary antioxidant capacity, salivary antioxidant concentration was significantly higher in the C than the S, SR, and CR groups on the tenth day of the experiment (p <0.05).ConclusionThe clinical effects in the CR group seem to be due to antioxidant, anti-bacterial and anti-inflammatory effects of cinnamaldehyde; this conclusion, however, requires further investigations. Delayed antioxidant effect in the CR group was evident in ip cinnamaldehyde injection, the exact mechanism is not clear.

Background: Oral mucosa which covers inside of the mouth is a complex structure that has been adapted for its particular function and anatomical location. Some oral conditions, despite their different physical features, are not pathological; rather, they are considered normal such as Linea Alba, Parotid Papilla, Geographic Tongue and Fissured Tongue. Materials and Methods: in this cross-sectional study 692 patients were registered through clinical examination and fulfillment of predesigned questionnaire. Diagnostic criteria in this study included the normal changes of the oral mucosa (including geographic tongue, fissured tongue, scalloped tongue, parotid papilla, palatal and mandibular torus, Lina Alba, frenal tag, leukoedema, Fordyce granules). Results: 692 people with an average age of 35years participated in this study. The overall sum of oral cavity normal variations was 806, 542 cases of which were female and 264 cases male. Conclusion: In this study 692 patients were examined by specialists; 494 cases, a sum of 71% had oral cavity normal variations. Linea Alba had the highest frequency among normal variations.

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