Oxaliplatin has been approved for adjuvant treatment of colorectal cancer. Toxicity induced by oxaliplatin is moderate and manageable, but some isolated cases of severe pulmonary toxicity associated to oxaliplatin have been reported. Two fatal cases of interstitial pneumonitis rapidly evolving to pulmonary fibrosis are reported here.

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Este es el caso de un varón afecto de un probable melanoma meníngeo que debuta con una paraplejia por compresión medular. El melanoma maligno de localización en el sistema nervioso central varía en las características citológicas mucho más que en otros lugares. En ocasiones puede resultar muy dificultosa e incluso imposible su precisa clasificación histológica. Paralelamente se revisará el tratamiento bioquimioterápico en este tipo de tumores.

Cancer are more than 100 complex conditions that builds a great challenge for health care systems and proffessionals. In the last years, the reality of cancer has evolved to different situations that we must face adapting the traditionally vertical organizations to the natural flow of cancer process that is horizontal. The major challenge is to organize the network of human and technological resources, available in our setting to achieve the best results.

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