No abstract

A cluster of unexplained pneumonia cases was reported in Wuhan, China, in late December 2019. A new coronavirus was identified as the causative cause of this mysterious pneumonia a few days later. The World Health Organization has temporarily given this causal virus the designation of severe acute respiratory syndrome coronavirus 2 and the related infected disease as coronavirus disease 2019 (COVID-19). The primary objective of this study is to examine the liver efficiency and assess the oxidative stress status of COVID-19 patients by measuring liver function enzymes, glutathione and MDA. The study included 120 cases ranging from 20 to 60 years, divided into three groups, COVID-19 patients, recovered, and control groups. Group. The results obtained indicated a significant increase in ALT, AST, and ALP activity (p< 0.01) in patients compared to those recovering ​​and control. The results also indicated a significant increase in MDA in contrast to a significant decrease in the GSH activity of COVID-19 patients compared to recovered and healthy subjects. These results reflect the strong relationship between COVID-19 and impaired liver function as well as impaired oxidative stress / antioxidant balance.

Corona viruses are members of the order nidovirales and the corona family. Coronaviruses (CoVs) are a family of closed-cell, positive-sense, single-stranded RNA viruses with a wide range of characteristics. They produce a variety of health problems in humans and animals and affect the respiratory, digestive, liver and nervous systems. In this study, kidney function tests, LDH and glucose were evaluated in COVID-19 patients. The study included 120 cases, who were divided into three groups; a first group of 40 patients with COVID-19, and the secondgroup of 40 recovered of COVID 19, and the third group was control of40. The results indicated a significant increase (P < 0.01) in the renal function parameters of Covid-19 patients compared to the recovered and control groups. The obtained results also indicated a significant increase in LDH and glucose levels (P<0.01) in patients compared to the recoverdand control values. Among these results, it appears that the Corona virus may affect and threateneverything that cause the failure of vital organs in the body.