In this study, new substituted 2-amino-3-cyanopyridine derivatives were synthesized in excellent yields by reacting chalcone derivatives with malanonitrile in the presence of ammonium acetate, and new complexes with these ligands were synthesized and characterized by elemental analysis, UV, IR, Mass, and NMR (1H, 13C) spectroscopy, and had the general formula: [ML2(H2O)2]Cl2 where M= Co(ІІ), Ni(ІІ) and Cu(ІІ), [ML2(H2O)Cl]Cl2 where M= Cr (ІІІ). On the basis of analytical data and IR studies, a 1:2 metal to ligand stoichiometry has been suggested to these coordination complexes. All of these studies suggest that the ligand acted as a bi-dentate ligand when it coordinates with metal ions, and that the prepared complexes had an octahedral geometry coordinated by both the nitrogen of (cyano group) and (amino group). The ligand and its complexes were tested for antimicrobial activity against gram negative (Pseudonomous aeruginosa) and gram positive (Bacillus subtitis) bacteria. All of these complexes have been shown to be more antibacterial than their respective ligands.

The 1,2, 3-triazole moiety is the main biomolecule formed from the chemistry of clicks. Click chemistry is cycloaddition reaction including Copper or ruthenium catalyzed with azide-alkyne and resulting in five membered rings. Click chemistry and its complexes are utilized as anti-cancer, anti-microbial, anti-tuberculosis, anti-viral, anti-diabetic, anti-malarial, ant?-leishmanial and neuroprotective agents and also in fluorescent technology. Biological targets required a method containing the linker feature like 1,2, 3-triazoles moiety and a new set of 1,2,3-triazole consisting hybrids and conjugates. The present review summarizes developments over the last few years in application complexes of 1,2, 3-triazole analogue. Scientists of organic fields, clinical chemistry, photochemistry, and pharmacology will benefit from this study. This review offers essential knowledge to the interested researchers.

A new metal-free macrocyclic Schiff base ligand bearing two metal cavities incorporated with two sets of N3O2 donor atoms derived from 2, 6-diaminopyridine and isatine was synthesized. The new ligand was used to prepare homo and hetero binuclear macrocyclic Schiff base complexes with Ni (II), Cu (II), ZrO (II) and Ba (II) metal ions. The ligand and metal complexes were characterized using Fourier transform infrared (FT-IR), UV–vis, mass spectroscopy, elemental analysis (CHN), thermo gravimetric analysis (TGA), magnetic susceptibility, and molar conductivity measurements. The DFT calculations using the B3LYP functional method have been applied to obtain the geometry and electronic properties of the ligand and its metal complexes to support the experimental data. To describe the reactivity of the title molecules, the HOMO and LUMO levels and Mulliken atomic charges were determined.