Background: Acne is reported to have a negative effect on mental health in adolescents. Aim of the work: Evaluation of the psychological effects of acne vulgaris amongst secondary school adolescents in DamiettaGovernorate. Patients and Methods:A cross-sectional study was completed on 172 students with acne vulgaris aged between 15-and 19years during the period extended from September 2019 to March 2020 in Damietta governorate schools from both sexes. Patients with disorders present before acne or other chronic diseases were excluded from the study. All patients were evaluated by the Arabic version of the Dermatology Life Quality Index [DLQI] to determine the dermatological quality of life [QOL] among acne cases.