Fused pyrimidine derivativesFused pyrimidine derivatives R 0515 Thiadiazolyl Quinazolones as Potential Antiviral and Antihypertensive Agents. -Compounds (IXa) and (IXb) show antiviral activity, while compound (IXc) shows antihypertensive activity. -(PANDEY*, V. K.; TUSI, S.; TUSI, Z.; RAGHUBIR, R.; DIXIT, M.; JOSHI, M. N.; BAJPAI, S. K.; Indian J.

A series of novel 4-amino-5-mercapto-3-[(3-aralkyl amido/imidoalkyl) phenyl]-1,2,4-triazoles (5a-d) were obtained by treating m-(aralkyl amido/imidoalkyl) benzoic acid hydrazides (3a-d) with carbon disulphide in alcoholic KOH and hydrazine hydrate, respectively. These triazole derivatives were employed in the synthesis of 5-[(3′-aralkyl amido/imidoalkyl) phenyl]-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines (6a-d). The newly synthesized compounds were evaluated for their antiviral activity against two animal viruses, namely, Japanese encephalitis virus (JEV) strain P20778 and herpes simplex virus-1 (HSV-1) strain 753166.

A Chemical Strategy for the Construction of Quinoline Isoquinoline Core Units. -A series of 9 title compounds of type (XIII) are prepared and screened for their biological activities. Compounds (XIIIb) and (XIIId) are active against 3 bacterial strains, whereas (XIIIa), (XIIIb) and (XIIId) show high to moderate antifungal activity. -(PANDEY*, V. K.; TUSI, S.; MISRA, R.; SHUKLA, R.; Indian J.