One of the industries significantly affected by the Covid-19 pandemic is tourism. As a result of lockdowns, tourism came to a halt, which has caused severe damages not only to tourism-related business but also aviation, hospitality sector, which resulted in unemployment, reduced work hours with minimum salary or temporary leave and even closure the businesses. As a result of the pandemic, 99 travel agencies liquidated their business activities and the revenues of 88 percent of the whole tourism sector reduced and 56 percent of employees were laid off. This paper analyses the impact of Work-related stress on the job satisfaction and organizational trust in the tourism sector during the unprecedented changes related to the Covid-19 pandemic. The survey was conducted online in April-May, 2021 and involved 275 employees working for different travel agencies. Numerous tests are used to verify the proposed hypothesis, such as factor analysis, reliability analysis, correlation analysis and PLS analysis. The results of the survey show that the Work-related stress caused by Covid-19 pandemic has a negative impact on job satisfaction and organizational trust among surveyed employees.