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Glimepiride [1][2][3][4] is the only third generation sulphonyl urea, which lowers the blood glucose level in the healthy subjects as well as in patients with type II diabetes. After oral administration, Glimepiride is completely (100%) absorbed from the GI tract. Studies with single oral doses in normal subjects and with multiple oral doses in patients with type II diabetes have shown significant absorption of Glimepiride within 1 hour after administration and peak drug levels (C max ) at 2 to 3 hours. Due to its low biological half life, it requires frequent administration to maintain plasma concentration. This leads fluctuations in plasma

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