After one hour the respective treatment 0.1 ml of 1% w/v Carrageenan suspension was injected subcutaneously into the plantar surface of the right hind paw. The paw volume was measured by using a plethysmometer immediately after 1, 2, 3, 4 h of carrageenan treatment. The anti- ABSTRACTThe anti-inflammatory activity of Vitex NegundoLinn was studied in carrageenan induced paw edema & cotton pellet granuloma in albino rats. The anti-inflammatory activity of the Ethanolic and aqueous extracts (100 & 200mg/kg) were evaluated against the carrageenan induced paw edema of rats were compared with the standard drug Indomethacin. The extract at the test doses of 100 and 200 mg/kg body weight reduced the paw edema induced by Carrageenan by 48.13% and 57.18% respectively, where as the standard drug showed 61.16. The paw edema suppressant effect was significant (P < 0.05) in the dose of 100&200mg/kg ethanol and aqueous extracts.When compared between control and two extracts, Ethanolic extract shows maximum anti-inflammatory activity. Thus it can be concluded that the extract of Vittex Negundo. Linn extract posses the anti-inflammatory activity.