The natural history and prognosis of MDS are classified by the International Prognostic Scoring System (IPSS) and Revised International Prognostic Scoring System (R-IPSS). In low-risk MDS (low or intermediate-1 IPSS or R-IPSS ≤ 3.5), anemia is the predominant feature, often leading to red blood cell (RBC) transfusion requirement, poor quality of life, and worsening cardiovascular comorbidities (Steensma and Bennett, 2006). Correcting anemia by transfusion support or enhancing intrinsic