No abstract

A versatile and high-yielding indium trichloride mediated cyclization reaction of silylated homoallylic alcohols, thiols, or amines with aldehydes or epoxides is described as a rapid route to a range of unsaturated heterocycles. The excellent diastereoselectivity observed offers a method of wide scope and generality.

A range of silicon-based tethers and promoters have been investigated for use in the development of a silyl-tethered Pauson-Khand reaction.